A direct method for the N-tetraalkylation of azamacrocycles

• Andrew J. Counsell,
• Angus T. Jones,
• Matthew H. Todd and
• Peter J. Rutledge

Beilstein J. Org. Chem. 2016, 12, 2457–2461, doi:10.3762/bjoc.12.239

• Andrew J. Counsell Angus T. Jones Matthew H. Todd Peter J. Rutledge School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia 10.3762/bjoc.12.239 Abstract An efficient protocol for the direct synthesis of N-tetraalkylated derivatives of the azamacrocycles cyclam and

• -tetra(prop-2-yn-1-yl)-1,4,8,11-tetraazacyclotetradecane diperchlorate is reported. Keywords: azamacrocycles; biphasic system; cyclam; cyclen; N-alkylation; Findings The tetraazamacrocycles cyclam (1) and cyclen (2) have been the subject of considerable interest over many years [1][2][3][4][5][6][7