Beilstein J. Org. Chem.2017,13, 644–647, doi:10.3762/bjoc.13.63
these building blocks provided access to a variety of derivatives including tetrahydrofurans, epoxides and protected amino-tetraols.
Keywords: azasugar; carbohydrate; cycloaddition; endoperoxide; photochemistry; Introduction
Azasugars are small organic compounds that can mimic carbohydrates or their
allow in-depth exploration of the chemistry of this class of azasugar precursors. Some preliminary experiments were performed to assess the possibilities that these building blocks grant.
Endperoxide 19 was epoxidized under standard conditions to provide the desired epoxide 25 and the anti-diol 26 as a
was encouraging and gave access to a variety of novel protected azasugar precursors. We conclude that the choice of amine and dihydroxy protecting groups can have an impact on the success of the endoperoxide synthesis and its thermal stability, and that employing phthalimide and acetonide groups for N
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Top: The natural product deoxynojirimycin and two analogues and marketed drugs Glyset and Zavesca. ...
Beilstein J. Org. Chem.2011,7, 699–716, doi:10.3762/bjoc.7.81
addition, the reaction conditions (temperature, solvents) currently employed in olefin metathesis reactions can be productively transferred to the metathesis steps of iminocyclitols synthesis.
By surveying the field of recent azasugar developments, this review focuses on metathesis reactions (mainly RCM
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Well-defined Mo- and Ru-alkylidene metathesis catalysts.