A concise and efficient synthesis of benzimidazo[1,2-c]quinazolines through CuI-catalyzed intramolecular N-arylations

• Xinlong Pang,
• Chao Chen,
• Ming Li and
• Chanjuan Xi

Beilstein J. Org. Chem. 2015, 11, 2365–2369, doi:10.3762/bjoc.11.258

• Science and Technology, Qingdao, 266042, China 10.3762/bjoc.11.258 Abstract A series of functionalized benzimidazo[1,2-c]quinazoline derivatives was obtained in excellent yields under mild conditions through a CuI-catalyzed Ullmann N-arylation starting from easily available starting materials. Keywords

• : benzimidazo[1,2-c]quinazoline; (bromophenyl)iodonium salt; copper catalyst; o-cyanoaniline; quinazolin-4(3H)-imine; Ullmann N-arylation; Introduction Nitrogen-containing heterocycles are ubiquitous backbones in natural products, medicine and organic materials. In addition, they are also important ligands for

• development of an efficient way to prepare various benzimidazo[1,2-c]quinazoline derivatives is highly desired. Although some methods for the synthesis of benzimidazo[1,2-c]quinazoline derivatives have been reported quite recently [7][8][9][10][11][12], they often require complicated starting materials that