Beilstein J. Org. Chem.2010,6, No. 45, doi:10.3762/bjoc.6.45
systems.
Keywords: benzodioxinopyridazine; 9,10-dioxa-1,2-diaza-anthracene; heterocyclic synthesis; nucleophilic aromatic substitution; perfluoroheteroaromatic; tetrafluoropyrazine; Introduction
Drug discovery programmes are continually searching for viable synthetic routes to highly novel classes of
]dioxino[2,3-c]pyridazine also referred to as benzodioxinopyridazine) systems are very rare heterocyclic structures and only a handful of analogues based upon this molecular skeleton have been synthesised, mainly by the reaction of chlorinated pyridazines with catechol [14][15][16].
In this paper, we
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Graphical Abstract
Scheme 1:
Synthesis of novel tricyclic heterocycles from pentafluoropyridine.