Beilstein J. Org. Chem.2022,18, 1416–1423, doi:10.3762/bjoc.18.147
and preparation of suitable salen compounds, sometimes are described as bis-imine Schiff bases. Imines were originally synthesized by Schiff from the condensation of carbonyls with amines [25]. Thereafter, syntheses of salens were extensively reported using timely technologies [26][27][28][29
Beilstein J. Org. Chem.2010,6, 1174–1179, doi:10.3762/bjoc.6.134
Anantapur, Anantapur 515002, Andhra Pradesh, India, Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, Andhra Pradesh, India 10.3762/bjoc.6.134 Abstract A bis-imine (prepared via a new FeCl3-based method) in combination with CoCl2 facilitated lipase-mediated
acetylation of the (R)-isomer of a racemic benzylic secondary alcohol with 91% ees. The methodology was used for the preparation of the known drug rivastigmine.
Keywords: acetylation; bis-imine; cobalt chloride; enantioselectivity; lipase; Introduction
The development and use of newer synthetic methods for
preliminary results on the synthesis and identification of a novel ligand for this process (Scheme 1) and its application in the preparation of the known drug rivastigmine [14]. While the uses of bis-imine/transition-metal complexes have been reported for the enantioselective synthesis of chiral compounds [15
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Graphical Abstract
Scheme 1:
Lipase-catalyzed acetylation of racemic benzylic secondary alcohol [(RS)-4] and its application.