Beilstein J. Org. Chem.2011,7, 668–677, doi:10.3762/bjoc.7.79
exhibit a broad spectrum of pharmacological activity such as antifungal, antibacterial, anti-inflammatory and anticancer etc. Triazoles have increased our ability to treat many fungal infections, for example, candidiasis, cryptococcal meningitis, aspergillosis etc. However, mortality due to these
we are entering a new era of antifungal therapy in which we will continue to be challenged by systemic fungal diseases, the options for treatment will have greatly expanded.
Keywords: antifungal; aspergillosis; candidiasis; cryptococcal meningitis; triazole; Review
Introduction
The alarming rates
that bioisosteric replacement of a triazole ring leads to antifungal activity with a higher selectivity of the fungal targets. Triazole antifungal drugs are used in the treatment of both superficial and deep-seated candidiasis [30]. On the basis of various literature surveys, the triazole nucleus