Beilstein J. Org. Chem.2023,19, 399–427, doi:10.3762/bjoc.19.31
called cyclic diaryl ether heptanoids (DAEH). This review is intended to highlight the structure elucidation, biosynthesis, and biological activity of these compounds as well as the use of different strategies for their synthesis.
Keywords: combretastatin D; corniculatolide; isocorniculatolide
was used to isolate the known compound corniculatolide A (4, 10 mg) as colorless crystals [14].
Later the same group reported the isolation of corniculatolide B (9), isocorniculatolide B (10), and corniculatolide C (11) from Xylocarpus granatum, a tree commonly found in Southeast Asia and along the
hexane/acetone/MeOH to 20% MeOH. From the six main fractions, three of them showed the new structures, corniculatolide B (9, 3 mg), isocorniculatolide B (10, 2 mg), and corniculatolide C (11, 5 mg), among some other known constituents. Different 1H and 13C NMR and HRESIMS techniques were employed to
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Graphical Abstract
Figure 1:
Structures of some members of the combretastatin D series, corniculatolides, and isocorniculatolide...