Beilstein J. Org. Chem.2014,10, 858–862, doi:10.3762/bjoc.10.82
isomers – cuevaenes A (1) and C (3) as well as cuevaenes D (4) and E (5) – and cuevaene B (2) were isolated from gdmAI-disrupted Streptomyces sp. LZ35. The constitution of cuevaene C (3) was found to be identical to cuevaene A (1) by means of NMR spectroscopy and high resolution mass spectrometry. However
, the relative configurations of the triene side chain moieties were determined to be different. It was established on the basis of spectroscopic data that cuevaenes D (4) and E (5) are amides and geometrical isomers. Cuevaenes A–C (1–3) displayed moderate activity against Gram-positive bacteria (e.g
., Bacillus subtilis strain ATCC 11060) and modest activity against fungi (e.g., Fusarium verticillioides strain S68 and Rhizoctonia solani strain GXE4). However, cuevaenes D (4) and E (5) showed no inhibitory activity against any of the tested microbes.
Keywords: antibacterial activity; cuevaenes
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Graphical Abstract
Figure 1:
Cuevaenes A–E (1–5) isolated from Streptomyces sp. LZ35.