One-pot cross-enyne metathesis (CEYM)–Diels–Alder reaction of gem-difluoropropargylic alkynes

• Santos Fustero,
• Paula Bello,
• Javier Miró,
• María Sánchez-Roselló,
• Günter Haufe and
• Carlos del Pozo

Beilstein J. Org. Chem. 2013, 9, 2688–2695, doi:10.3762/bjoc.9.305

• starting materials. In this context, the recent introduction of difluoropropargyl bromide as fluorinated building block gave access to a wide variety of gem-difluoro-containing alkyne derivatives [21][22]. Recently, we have employed these fluorinated triple bond scaffolds in several types of cyclization

Synthesis of fluorinated δ-lactams via cycloisomerization of gem-difluoropropargyl amides

• Satoru Arimitsu and
• Gerald B. Hammond

Beilstein J. Org. Chem. 2010, 6, No. 48, doi:10.3762/bjoc.6.48

• ; cycloisomerization; difluoropropargyl; enyne; ring-closing metathesis; Introduction It has been estimated that as many as 25% of all synthetic pharmaceutical drugs contain an amide bond [1]. Commonly, β- and γ-lactams are present in many natural products and pharmaceuticals, and the introduction of a gem

• fluorinated δ-lactams via cycloisomerization of gem-difluoropropargyl amides Acknowledgements We are grateful to the National Science Foundation for financial support (CHE-0809683) and to Professor Santos Fustero, Universidad de Valencia, Spain, for scientific cooperation and advice.