Beilstein J. Org. Chem.2023,19, 1299–1369, doi:10.3762/bjoc.19.96
with the development of edelfosine (an anticancer drug). More recently, ohmline, a glyco glycero ether lipid that modulates selectively SK3 ion channels and reduces in vivo the occurrence of bone metastases, and other glyco glycero ether also identified as GAEL (glycosylated antitumor ether lipids
compounds.
Keywords: amphiphiles; edelfosine; GAEL; glycerol lipids; glycolipids; ohmline; plasmalogen; Introduction
Ether lipids (ELs) are natural compounds that feature a glycerol unit linked with an ether function to an alkyl (alkyl acyl ether lipid) or alkenyl (plasmalogen) lipid chain. For the
) myo-inositol (20.6). The oxidation of the phosphite intermediate with m-CPBA followed by the catalytic hydrogenolysis of the benzyl protecting groups produced PIP3-PAF (20.7).
2 Edelfosine and diether analogues
PAF and PAF-analogues that feature an acyl or more generally an ester group in sn-2
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Graphical Abstract
Figure 1:
Chemical structure of some natural ether lipids (ELs).