Beilstein J. Org. Chem.2016,12, 2325–2342, doi:10.3762/bjoc.12.226
uncultured bacterial source, and demonstrates remarkably high potency against a wide range of resistant pathogens without apparent development of resistance. A rare amino acid residue component of teixobactin, enduracididine, is only known to occur in a small number of natural products that also possess
promising antibiotic activity. This review highlights the presence of enduracididine in natural products, its biosynthesis together with a review of analogues of enduracididine. Reported synthetic approaches to the cyclic guanidine structure of enduracididine are discussed, illustrating the challenges
encountered to date in the development of efficient synthetic routes to facilitate drug discovery efforts inspired by the discovery of teixobactin.
Keywords: amino acid; bacterial resistance; enduracididine; natural products; peptide antibiotics; Review
Introduction
The enduracididines
The enduracididines
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Graphical Abstract
Figure 1:
Structures of the enduracididine family of amino acids (1–6).