Cytochrome P450 monooxygenase-mediated tailoring of triterpenoids and steroids in plants

• Karan Malhotra and
• Jakob Franke

Beilstein J. Org. Chem. 2022, 18, 1289–1310, doi:10.3762/bjoc.18.135

• -dihydroxycucurbitadienol to form trihydroxylated mogrol in yeast [102]. CYPs acting on pentacyclic 6-6-6-6-6 triterpenes, which include the extremely important and widespread scaffolds β-amyrin (6), α-amyrin (7), and friedelin (8), are summarised in Figure 4. Of particular relevance in this area is the CYP716 family

• celastrol, a potent anti-obesity metabolite [42][43]. In two independent studies, transcriptome mining and functional studies in Nicotiana benthamiana were used to identify the CYPs CYP712K1, CYP712K2, CYP712K3, and CYP712K4 capable of oxidising friedelin (8) into polpunonic acid via an aldehyde

Genicunolide A, B and C: three new triterpenoids from Euphorbia geniculata

• Alia Farozi,
• Javid A. Banday and
• Shakeel A. Shah

Beilstein J. Org. Chem. 2015, 11, 2707–2712, doi:10.3762/bjoc.11.291

• Alia Farozi Javid A. Banday Shakeel A. Shah Department of Chemistry, National Institute of Technology, Hazratbal, Srinagar-190006, J&K, India, Tel.: +91 9906626635 10.3762/bjoc.11.291 Abstract Three new triterpenoids, designated as genicunolide A (1), B (2) and C (3), along with friedelin (4) and

• . Keywords: Euphorbiaceae; Euphorbia geniculata; friedelin; friedelinol; genicunolide A; B; C; pentacyclic triterpenoids; Introduction Euphorbia (Euphorbiaceae) is a very large and diverse genus of flowering plants comprising of about 2,000 members and is found all over the world, ranging from short annual

• , designated as genicunolide A (1), B (2) and C (3), together with friedelin (4) [31] and friedelinol (5) [32], from the ethyl acetate extract of the aerial parts of the plant. Herein, we report the characterization of the three compounds by spectral and chemical methods. Results and Discussion The compounds 1