Highly bulky and stable geometry-constrained iminopyridines: Synthesis, structure and application in Pd-catalyzed Suzuki coupling of aryl chlorides

• Yi Lai,
• Zhijian Zong,
• Yujie Tang,
• Weimin Mo,
• Nan Sun,
• Baoxiang Hu,
• Zhenlu Shen,
• Liqun Jin,
• Wen-hua Sun and
• Xinquan Hu

Beilstein J. Org. Chem. 2017, 13, 213–221, doi:10.3762/bjoc.13.24

• Physics, Chinese Academy of Sciences, Lanzhou 730000, P.R. China Key laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China 10.3762/bjoc.13.24 Abstract A series of bulky geometry-constrained

• activities in the coupling reaction of aryl chlorides. Keywords: aryl chloride; geometry-constrained; iminopyridyl; palladium; Suzuki; Introduction Palladium-promoted C–C coupling reactions are recognized as one of the most powerful tools in organic syntheses, pharmaceutical processes and biological

• wide variety of different substituents were introduced leading to a diversity with regard to steric and electronic aspects [54][55][56][57][58][59]. Recently, we have developed a series of geometry-constrained iminopyridyl compounds [60][61][62][63][64] and their corresponding palladium complexes