Beilstein J. Org. Chem.2015,11, 848–849, doi:10.3762/bjoc.11.94
Rainer Haag Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany 10.3762/bjoc.11.94 Keywords: glycoarchitectures; supramolecular chemistry; multivalency; multivalent protein inhibitors; pathogen binding; Multivalency is a key principle in nature
supramolecular designer systems [4][5]. The influence of spacer length and flexibility on the binding affinity of ligands [6] will be examined as well as the mechanical stability of complexes [7]. Furthermore, the Thematic Series covers the synthesis of various new glycoarchitectures for multivalent interactions
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Figure 1:
Multivalent interactions shift the equilibrium and enhance the binding strength. Reprinted with per...