Synthesis of carbohydrate-scaffolded thymine glycoconjugates to organize multivalency

• Anna K. Ciuk and
• Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2015, 11, 668–674, doi:10.3762/bjoc.11.75

• other way. These processes allow to control, regulate and fine-tune the complex life of eukaryotes. We have recently focused our research dedicated to multivalency effects in carbohydrate recognition on the aspect of conformational control of multivalent assemblies, such as micelles [5] or glycoarrays

Synthesis and testing of the first azobenzene mannobioside as photoswitchable ligand for the bacterial lectin FimH

• Vijayanand Chandrasekaran,
• Katharina Kolbe,
• Femke Beiroth and
• Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2013, 9, 223–233, doi:10.3762/bjoc.9.26

• supports such as oligofunctional core molecules [15] or surfaces, to achieve switchable adhesive surfaces in continuation of our work on glycoarrays [16][17][18] (Figure 1D). In this account, we describe the synthesis of the azobenzene mannobioside 2 as well as of mannoside 6, investigation of their

S-Fluorenylmethyl protection of the cysteine side chain upon N^α-Fmoc deprotection

• Johannes W. Wehner and
• Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2012, 8, 2149–2155, doi:10.3762/bjoc.8.242

• methods, NCL or SPPS. In addition, mannosidic glycoamino acids are of interest as ligands for mannose-specific lectins in solution [17] as well as for the fabrication of glycoarrays on solid support [10][18][19]. Moreover, we are interested to advance glycoamino acid deriatives such as 3 into ligands that

Formation of carbohydrate-functionalised polystyrene and glass slides and their analysis by MALDI-TOF MS

• Martin J. Weissenborn,
• Johannes W. Wehner,
• Christopher J. Gray,
• Robert Šardzík,
• Claire E. Eyers,
• Thisbe K. Lindhorst and
• Sabine L. Flitsch

Beilstein J. Org. Chem. 2012, 8, 753–762, doi:10.3762/bjoc.8.86

• glycoarrays [2][29][30]. As observed with the polystyrene slides, the resolution and signal intensity of MALDI-TOF MS analysis (Figure 2) was dramatically improved following application of the aluminium tape to the back of the glass slides. Next, the limit of detection of MS analysis of aluminium-backed

Preparation of aminoethyl glycosides for glycoconjugation

• Robert Šardzík,
• Gavin T. Noble,
• Martin J. Weissenborn,
• Andrew Martin,
• Simon J. Webb and
• Sabine L. Flitsch

Beilstein J. Org. Chem. 2010, 6, 699–703, doi:10.3762/bjoc.6.81

• ; glycoarrays; glycoconjugation; glycosylation; Introduction The chemical conjugation of carbohydrates through the anomeric centre to biomolecules such as peptides, proteins, lipids, metabolites and to array surfaces is an important synthetic challenge [1][2][3][4][5]. A diverse range of linkers and spacers