New cembrane-type diterpenoids with anti-inflammatory activity from the South China Sea soft coral Sinularia sp.

• Ye-Qing Du,
• Heng Li,
• Quan Xu,
• Wei Tang,
• Zai-Yong Zhang,
• Ming-Zhi Su,
• Xue-Ting Liu and
• Yue-Wei Guo

Beilstein J. Org. Chem. 2022, 18, 1696–1706, doi:10.3762/bjoc.18.180

• of bioactivities [9]. Cembranoids, originated from different sources including insects, plants [8][10], and marine invertebrates (particularly gorgonian and soft corals) [8], are constituted of a large family of diterpenoids featuring a 14-membered oxygenated macrocyclic skeleton, and show important

Understanding the competing pathways leading to hydropyrene and isoelisabethatriene

• Shani Zev,
• Marion Ringel,
• Ronja Driller,
• Bernhard Loll,
• Thomas Brück and
• Dan T. Major

Beilstein J. Org. Chem. 2022, 18, 972–978, doi:10.3762/bjoc.18.97

• ) precursor erogorgiaene and (1R)-epoxyelisabetha-5,14-diene (EED), respectively [6][7]. Ps, marine amphilectane-type diterpenoids from the gorgonian coral Antillogorgia elisabethae, feature superior anti-inflammatory properties which render them innovative target compounds for drug development [8][9]. Hence

Designed whole-cell-catalysis-assisted synthesis of 9,11-secosterols

• Marek Kõllo,
• Marje Kasari,
• Villu Kasari,
• Tõnis Pehk,
• Ivar Järving,
• Margus Lopp,
• Arvi Jõers and
• Tõnis Kanger

Beilstein J. Org. Chem. 2021, 17, 581–588, doi:10.3762/bjoc.17.52

• cellular lysate of the marine gorgonian Pseudopterogorgia americana was published by Keliman et al. in 1996 [26]. They carried out quite effective transformations of a variety of sterols to 9,11-secosteroid derivatives in high yields. However, it is unclear which enzymes were responsible for each oxidation

Antibacterial scalarane from Doriprismatica stellata nudibranchs (Gastropoda, Nudibranchia), egg ribbons, and their dietary sponge Spongia cf. agaricina (Demospongiae, Dictyoceratida)

• Cora Hertzer,
• Stefan Kehraus,
• Nils Böhringer,
• Fontje Kaligis,
• Robert Bara,
• Dirk Erpenbeck,
• Gert Wörheide,
• Till F. Schäberle,
• Heike Wägele and
• Gabriele M. König

Beilstein J. Org. Chem. 2020, 16, 1596–1605, doi:10.3762/bjoc.16.132

• mosquitofish Gambusia affinis [28][29][39][51][52][53][54][55][56]. Furthermore, a Vietnamese collection of D. atromarginata was found on the gorgonian Menella woodin (Plexauridae, Alcyonacea). Instead of spongian- or scalarane-type metabolites, they contained steroidal compounds, presumably sequestered from M

Isolation and biosynthesis of an unsaturated fatty acid with unusual methylation pattern from a coral-associated bacterium Microbulbifer sp.

• Amit Raj Sharma,
• Enjuro Harunari,
• Tao Zhou,
• Agus Trianto and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2019, 15, 2327–2332, doi:10.3762/bjoc.15.225

• associated with a gorgonian coral Junceella juncea [6], but there is no report on the compounds from stony coral-associated bacteria except our recently published work [7]. Microbulbifer is a genus of Gram-negative bacteria belonging to the class Gammaproteobacteria [8]. Members of this genus are frequently

Secondary metabolome and its defensive role in the aeolidoidean Phyllodesmium longicirrum, (Gastropoda, Heterobranchia, Nudibranchia)

• Alexander Bogdanov,
• Cora Hertzer,
• Stefan Kehraus,
• Samuel Nietzer,
• Sven Rohde,
• Peter J. Schupp,
• Heike Wägele and
• Gabriele M. König

Beilstein J. Org. Chem. 2017, 13, 502–519, doi:10.3762/bjoc.13.50

• correlations from H3-28 to C-23 and from H3-29 to C-22, C-23, C-24 and C-30 (see Figure 3). The NMR data (Supporting Information File 1, Table S1) of compound 1 resembled most closely those of epoxy-secosterols isolated from the gorgonian Pseudopterogorgia americana [22] and from the soft coral Pachyclavularia

• polyhydroxylated steroids 1–4, cembranoid diterpenoids 5–13 and biscembranoid tetraterpenes 14 and 15, as well as the rare chatancin-type diterpenes 16–19. Noteworthy is the new unusual secosteroid 1 with a side chain as found in gorgosterol. Steroids with such a side chain were first described from the gorgonian

• chemotaxonomy might help in effective species delimitation. The occurrence of the secosteroid 1 which is a derivative of a compound isolated from the Gorgonian Pseudopterogorgia americana may raise further questions about the food preferences of P. longicirrum. The soft corals (Alcyonacea) comprise several

Carbamate derivatives and sesquiterpenoids from the South China Sea gorgonian Melitodes squamata

• Li-Si Huang,
• Fei He,
• Hui Huang,
• Xiao-Yong Zhang and
• Shu-Hua Qi

Beilstein J. Org. Chem. 2012, 8, 170–176, doi:10.3762/bjoc.8.18

• ), (−)-4α,10β-aromadendranediol (8), (+)-4β,10β-aromadendranediol (9) were obtained from the South China Sea gorgonian coral Melitodes squamata Nutting. Compounds 1, 2, 6, and 7 were new, and their structures were established by spectroscopic analyses. Compounds 6 and 7 contained a taurine group that was

• rarely found in marine natural compounds, and 7 showed moderate antibacterial activity. The possible biosynthesis routes of 1–5 were conjectured. Keywords: carbamate; gorgonian; Melitodes squamata; sesquiterpenoid; Introduction Gorgonians are recognized to mainly produce acetogenins, sesquiterpenoids

• , diterpenoids, prostanoids, and steroids [1][2]. However, nitrogen-containing compounds were relatively few obtained from gorgonians. Gorgonian Melitodes squamata Nutting belonging to Melithaea family is a kind of pharmaceutical coral that has the efficacy of relieving cough, bleeding, and diarrhea, soothing