A systems-based framework to computationally describe putative transcription factors and signaling pathways regulating glycan biosynthesis

• Theodore Groth,
• Rudiyanto Gunawan and
• Sriram Neelamegham

Beilstein J. Org. Chem. 2021, 17, 1712–1724, doi:10.3762/bjoc.17.119

• may regulate pathways related to sialylation, hyaluronan synthesis, as well as chondroitin and dermatan sulfate elongation. Here, STAT1, 4, and 5 proteins were enriched in the IL-21 signaling pathway. Luminal breast cancer types are known to express STAT1 and 3 as well as STATs 2 and 4. STAT5 is known

• are critical for heparin sulfate function include the HS2/3/6ST sulfotransferases, the GlcA epimerase GLCE, and additional enzymes mediating N-sulfation (i.e., NDSTs). 11) Hyaluronan synthesis: This pathway consists of the three hyaluronan synthases, HAS1–3. 12) Glycophosphatidylinositol (GPI) anchor

Strategies toward protecting group-free glycosylation through selective activation of the anomeric center

• A. Michael Downey and
• Michal Hocek

Beilstein J. Org. Chem. 2017, 13, 1239–1279, doi:10.3762/bjoc.13.123

Synthesis of a hexasaccharide partial sequence of hyaluronan for click chemistry and more

• Marina Bantzi,
• Stephan Rigol and
• Athanassios Giannis

Beilstein J. Org. Chem. 2015, 11, 604–607, doi:10.3762/bjoc.11.67

• Abstract In the present work, the synthesis of a hexasaccharide partial sequence of hyaluronan equipped with a terminal azido moiety is reported. This hexasaccharide can be used for the attachment on surfaces by means of click chemistry and after suitable deprotection for biophysical studies. Keywords

• : azide; click chemistry; extracellular matrix; hexasaccharide; hyaluronan; multivalency; Introduction Much effort has been exerted during the last years to refine current knowledge about the biology of the extracellular matrix (ECM) [1]. While in the past, it was only regarded as a “space filler” among

• elucidated in 1954 [6] and since 1986 it is known as “hyaluronan” (HA) [7]. HA is an unbranched polysaccharide, whose disaccharide repeating unit consists of N-acetylglucosamine and D-glucuronic acid conjoined through β-(1→3) and β-(1→4)-glycosidic bonds. Hyaluronan has an average size of 15–20 kDa and does