A new and efficient procedure for the synthesis of hexahydropyrimidine-fused 1,4-naphthoquinones

• Marcelo Isidoro P. Reis,
• Vinícius R. Campos,
• Jackson A. L. C. Resende,
• Fernando C. Silva and
• Vitor F. Ferreira

Beilstein J. Org. Chem. 2015, 11, 1235–1240, doi:10.3762/bjoc.11.137

• , Campus do Valonguinho, 24020-150, Niterói, RJ, Brazil 10.3762/bjoc.11.137 Abstract A new and efficient method for the synthesis of hexahydropyrimidine-fused 1,4-naphthoquinones in one step with high yields from the reaction of lawsone with 1,3,5-triazinanes was developed. Keywords: hydrobenzo[g

• ]quinazoline; microwave; naphthoquinone; 1,3-quinazoline; 1,3,5-triazinane; Introduction Quinones represent a diverse family of naturally occurring secondary metabolites [1][2][3]. Interest in these substances has intensified in recent years due to their pharmacological importance [4]. Heterocycle-fused