Continuous-flow processes for the catalytic partial hydrogenation reaction of alkynes

• Carmen Moreno-Marrodan,
• Francesca Liguori and
• Pierluigi Barbaro

Beilstein J. Org. Chem. 2017, 13, 734–754, doi:10.3762/bjoc.13.73

• as “reaction modifiers”, or metal ions (Cu, Pb) [72], polymers/surfactants [73] defined “catalyst modifiers”, whose common purpose is to decrease the hyperactivity of the (Pd) metal. It is clear that, besides the use and consumption of toxic/expensive substances, drawbacks in terms of catalyst reuse

New efficient ligand for sub-mol % copper-catalyzed C–N cross-coupling reactions running under air

• Per-Fredrik Larsson,
• Peter Astvik and
• Per-Ola Norrby

Beilstein J. Org. Chem. 2012, 8, 1909–1915, doi:10.3762/bjoc.8.221

• for sub-mol % copper-catalyzed C–N cross-coupling reactions. The efficiency of the ligand was determined by kinetic methods. DMDETA proved to display efficiency similar to DMEDA and, in addition, the resulting catalyst was tolerant to air. Keywords: copper; cross coupling; hyperactivity; kinetics

Palladium- and copper-mediated N-aryl bond formation reactions for the synthesis of biological active compounds

• Carolin Fischer and
• Burkhard Koenig

Beilstein J. Org. Chem. 2011, 7, 59–74, doi:10.3762/bjoc.7.10

• synthesis of an atropisomeric N-(2-tert-butylphenyl)lactam as an intermediate for norepinephrine transporter (NET) inhibitor 16. NET inhibitors were developed to treat a variety of mental disorders such as depression and attention deficit hyperactivity disorder (ADHD). Screening different ligands, SERGPHOS