Metathesis access to monocyclic iminocyclitol-based therapeutic agents

• Ileana Dragutan,
• Valerian Dragutan,
• Carmen Mitan,
• Hermanus C.M. Vosloo,
• Lionel Delaude and
• Albert Demonceau

Beilstein J. Org. Chem. 2011, 7, 699–716, doi:10.3762/bjoc.7.81

• , Potchefstroom 2520, South Africa Macromolecular Chemistry and Organic Catalysis, Institute of Chemistry (B6a), University of Liège, Sart Tilman, Liège 4000, Belgium 10.3762/bjoc.7.81 Abstract By focusing on recent developments on natural and non-natural azasugars (iminocyclitols), this review bolsters the case

• for the role of olefin metathesis reactions (RCM, CM) as key transformations in the multistep syntheses of pyrrolidine-, piperidine- and azepane-based iminocyclitols, as important therapeutic agents against a range of common diseases and as tools for studying metabolic disorders. Considerable

• ; iminocyclitols; natural products; olefin metathesis; Ru-alkylidene catalysts; Review Introduction Synthetic and natural polyhydroxylated N-heterocyclic compounds (pyrrolidines, piperidines, piperazines, indolizines, etc., and higher homologues), commonly referred to as azasugars, iminosugars or iminocyclitols