Beilstein J. Org. Chem.2023,19, 808–819, doi:10.3762/bjoc.19.61
synthesis; isoquinolin-4-ones; primary thioamides; structure–reactivity relationships; Introduction
During several past years, we have developed [1][2] a novel synthetic approach toward (Z)-3-[amino(phenyl/methyl)methylidene]-1,3-dihydro-2H-indol-2-ones and have demonstrated [3][4] its application
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Graphical Abstract
Scheme 1:
Eschenmoser coupling reaction between 3-substituted oxindoles and thioamides.