Natural phenolic metabolites with anti-angiogenic properties – a review from the chemical point of view

• Qiu Sun,
• Jörg Heilmann and
• Burkhard König

Beilstein J. Org. Chem. 2015, 11, 249–264, doi:10.3762/bjoc.11.28

• on the investigation of the aglycones. Although this has been often criticized, it is most likely an important aspect with regard to flavonoid metabolism. It has been shown that the flavonoid glycosides are not absorbed after oral intake but are cleaved by lactase-phlorizin hydrolase and absorbed as

Release of β-galactosidase from poloxamine/α-cyclodextrin hydrogels

• César A. Estévez,
• José Ramón Isasi,
• Eneko Larrañeta and
• Itziar Vélaz

Beilstein J. Org. Chem. 2014, 10, 3127–3135, doi:10.3762/bjoc.10.330

• Cesar A. Estevez Jose Ramon Isasi Eneko Larraneta Itziar Velaz Departamento de Química y Edafología, University of Navarra. C/ Irunlarrea s/n. 31008 Pamplona, Navarra, Spain 10.3762/bjoc.10.330 Abstract All mammals lose their ability to produce lactase (β-galactosidase), the enzyme that cleaves

• lactose into galactose and glucose, after weaning. The prevalence of lactase deficiency (LD) spans from 2 to 15% among northern Europeans, to nearly 100% among Asians. Following lactose consumption, people with LD often experience gastrointestinal symptoms such as abdominal pain, bowel distension, cramps

• : controlled release; cyclodextrins; lactase; polypseudorotaxane; supramolecular gel; Introduction In the Western diet, carbohydrates contribute about 50% of calories, distributed in the following ratio: starch (50%), sucrose (30%), lactose (6%), maltose (1–2%), and others (12%: trehalose, glucose, fructose

Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors

• Davide Bini,
• Francesca Cardona,
• Matilde Forcella,
• Camilla Parmeggiani,
• Paolo Parenti,
• Francesco Nicotra and
• Laura Cipolla

Beilstein J. Org. Chem. 2012, 8, 514–521, doi:10.3762/bjoc.8.58

• compounds in terms of their inhibitory activity against other glycosidases of interest, such as maltase, isomaltase, sucrase, glucoamylase, lactase and α-amylase. Experimental Synthesis General methods Solvents were dried over molecular sieves for at least 24 h prior to use, when required. When dry