Beilstein J. Org. Chem.2023,19, 1161–1169, doi:10.3762/bjoc.19.84
Chemical exploration of solid-state cultures of the polypore Fomitopsis carnea afforded two new C31 lanostane-type triterpenoid glycosides, forpiniosides B (1) and C (2) together with two known derivatives, namely 3-epipachymic acid (3) and (3α,25S)-3-O-malonyl-23-oxolanost-8,24(31)-dien-26-oic acid (4
against Staphylococcus aureus and Bacillus subtilis at MIC values comparable to gentamycin and oxytetracycline (positive controls), respectively.
Keywords: antimicrobial activity; Fomitopsis carnea; lanostane glycosides; Polyporales; Introduction
Great success was realized on antibiotic discovery
well-known profuse production of bioactive molecules, Basidiomycota have already been proven to be a valuable source for new anti-infectives [4]. These include a myriad of triterpenoids which have been resourceful in the discovery of potent antimicrobials [5]. Specifically, lanostane triterpenoids are
Beilstein J. Org. Chem.2013,9, 1333–1339, doi:10.3762/bjoc.9.150
-lanostane triterpenoids 1–3, one new cycloartane triterpenoid 4 along with fourteen known terpenoids. Structure determinations were based on extensive 1D/2D NMR, IR and MS spectroscopic analyses, and comparison with literature data. The isolated compounds were evaluated in vitro for their cytotoxicity
; lanostane; oleoresin; triterpenoids; Introduction
The genus Abies (Pinaceae) comprises 46 species of evergreen conifers [1]. Most of them are found in temperate and boreal regions of the northern hemisphere. The first phytochemical investigation of Abies species was undertaken 75 years ago by Takahashi [2
tetraterpenoids from the cortical oleoresin of the tree bark, featuring an unprecedented C40 scaffold [6]. Herein, we describe the further phytochemical study of A. balsamea oleoresin, which led to the isolation and structure elucidation of three 3,4-seco-lanostane-type triterpenoids 1–3, one cycloartane-type