Base-free enantioselective S_N2 alkylation of 2-oxindoles via bifunctional phase-transfer catalysis

• Mili Litvajova,
• Emiliano Sorrentino,
• Brendan Twamley and
• Stephen J. Connon

Beilstein J. Org. Chem. 2021, 17, 2287–2294, doi:10.3762/bjoc.17.146

• Mili Litvajova Emiliano Sorrentino Brendan Twamley Stephen J. Connon School of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland 10.3762/bjoc.17.146 Abstract N-Protected oxindole derivatives of unprecedented malleability bearing

Mechanical stability of bivalent transition metal complexes analyzed by single-molecule force spectroscopy

• Manuel Gensler,
• Christian Eidamshaus,
• Maurice Taszarek,
• Hans-Ulrich Reissig and
• Jürgen P. Rabe

Beilstein J. Org. Chem. 2015, 11, 817–827, doi:10.3762/bjoc.11.91

• 10.3762/bjoc.11.91 Abstract Multivalent biomolecular interactions allow for a balanced interplay of mechanical stability and malleability, and nature makes widely use of it. For instance, systems of similar thermal stability may have very different rupture forces. Thus it is of paramount interest to study

• systems. Keywords: molecular rupture mechanism; multivalency; malleability; pyridine coordination compounds; scanning force microscopy; Introduction In a multivalent molecular system, two partners interact with each other through two or more non-covalent equivalent interaction centers. This principle is

• be used to study selected parameters [4][5]. The mechanical stability of a molecular system is characterized by its rupture forces under a given loading rate. Malleability describes the ability of a protein complex or bond to deform without being disrupted and is characterized by the rupture length