NMR reaction monitoring in flow synthesis

• M. Victoria Gomez and
• Antonio de la Hoz

Beilstein J. Org. Chem. 2017, 13, 285–300, doi:10.3762/bjoc.13.31

• optimization is discussed. Keywords: expert systems; flow chemistry; microcoil; NMR probes; Introduction New enabling technologies have facilitated the transition from traditional chemistry to a more automated approach that will be the chemistry of the 21st century [1][2]. The objective is that the reaction

• breakage of glass sample tubes. Microcoil probes An interesting way to increase the sensitivity of NMR is the use of microcoil probes [15][16]. Based on the reciprocity principle [15], it has been shown that for a constant length-to-diameter ratio, the NMR detector (i.e., coil) sensitivity is inversely

• requirements for the spatial B0 field homogeneity, the construction of the probe for the highest sensitivity and resolution is a challenging task. The latter falls outside the scope of this review and instead, we will describe the types and features of microcoil probes in this section and its integration with