Assembly of synthetic Aβ miniamyloids on polyol templates

• Sebastian Nils Fischer and
• Armin Geyer

Beilstein J. Org. Chem. 2015, 11, 2646–2653, doi:10.3762/bjoc.11.284

• ; boronic acid; miniamyloids; NMR spectroscopy; peptides; Introduction Aβ peptides spontaneously form amyloid fibrils which are a major component of Alzheimer plaques [1]. The cooperative thermodynamically-driven process of fibril formation has an induction period which depends on the conditions of amyloid

• (Figure 1) [4]. Based on the concept of the existence of toxic Aβ oligomers, we recently developed covalently linked dimers of Aβ epitopes – so called synthetic Aβ miniamyloids – and successfully characterized their neurotoxicity [5]. These oligomeric peptides do not show an unmitigated fibrillation. The

• the first step of Aβ oligomerization. In the present article, we further develop the idea of systematic variation of the oligomerization degree of Aβ fragments by using dynamic covalent chemistry for the assembly of miniamyloids. The size of a polyol template will limit the aggregation degree of Aβ