Versatile synthesis of the signaling peptide glorin

• Robert Barnett,
• Daniel Raszkowski,
• Thomas Winckler and
• Pierre Stallforth

Beilstein J. Org. Chem. 2017, 13, 247–250, doi:10.3762/bjoc.13.27

• as well as in the design of chemical probes to dissect glorin-mediated signaling pathways. Keywords: Dictyostelium; glorin; multicellularity; Polysphondylium; signaling molecules; social amoebae; Introduction The emergence of multicellularity from unicellular ancestors is considered a major

• study the emergence of multicellularity since they can exist in both a unicellular and a multicellular stage with a well-orchestrated developmental cycle linking the two [2]. The unicellular amoebae feed on bacteria and divide by binary fission. Upon depletion of their food source, they aggregate to

• numerous species of social amoebae such as Polysphondylium pallidum, Dictyostelium fasciculatum [11], and D. caveatum [12], amongst others respond chemotactically to glorin (1), the acrasin has only been isolated from P. violaceum [13]. Despite its crucial role in the initiation of multicellularity, little