Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process

• Muthumani Muthu,
• Rakkappan Vishnu Priya,
• Abdulrahman I. Almansour,
• Raju Suresh Kumar and
• Raju Ranjith Kumar

Beilstein J. Org. Chem. 2018, 14, 2907–2915, doi:10.3762/bjoc.14.269

• ]pyridine has been reported as inhibitors of cytochrome P450 [33]. Furthermore, muscopyridine is being used in perfume industry [34]. Among the several methods available for the synthesis of pyridines or cycloalkyl-fused pyridines [23][24][25][26][27][35][36][37][38][39][40][41][42][43][44], the one-pot

Beyond catalyst deactivation: cross-metathesis involving olefins containing N-heteroaromatics

• Kevin Lafaye,
• Cyril Bosset,
• Lionel Nicolas,
• Amandine Guérinot and
• Janine Cossy

Beilstein J. Org. Chem. 2015, 11, 2223–2241, doi:10.3762/bjoc.11.241

• -dihydroquinolizinium salts (Scheme 13) [50]. In their synthetic approach towards (R)-(+)-muscopyridine, Fürstner and Leitner have constructed the 13-membered ring macrocycle using a RCM applied to diene 34 [51]. In order to avoid the catalyst deactivation due to the presence of the pyridine moiety, the precursor 34

• was first treated with HCl to form the corresponding hydrochloride salt which was then reacted with the ruthenium catalyst 36 under diluted conditions to deliver 35. After reduction of the double bond, the targeted (R)-(+)-muscopyridine was isolated (Scheme 14). A similar strategy was used in the

• . Enyne ring-closing metathesis. Synthesis of (R)-(+)-muscopyridine using a RCM strategy. Synthesis of a tris-pyrrole macrocycle. Synthesis of a bicyclic imidazole. RCM using Schrock’s catalyst 44. Synthesis of 1,6-pyrido-diazocine 46 by using a RCM. Synthesis of fused pyrimido-azepines through RCM. RCM

Selected synthetic strategies to cyclophanes

• Sambasivarao Kotha,
• Mukesh E. Shirbhate and
• Gopalkrushna T. Waghule

Beilstein J. Org. Chem. 2015, 11, 1274–1331, doi:10.3762/bjoc.11.142

• cyclophanes. To keep the length of the review at a manageable level the literature related to orthocyclophanes was not included. Keywords: addition reactions; coupling reactions; cyclophane; metathesis; muscopyridine; name reactions; natural products; Indroduction Cyclophanes [1][2][3][4][5][6][7][8][9][10

• saturated alkyl chain (22), whereas the unsaturated turrianes 23, 24 containing a (Z)-alkene moiety have been prepared by alkyne metathesis followed by reduction using Lindlar’s catalyst (Figure 5). Muscopyridine and its analogues Musk is a widly used component in Chinese pharmaceuticals and it has also

• been used in perfume industry. Muscopyridine was first isolated by a Swiss group [83] from the musk deer (Moschus moschiferus). Muscopyridine and its synthetical analogue normuscopyridine are heterophanes, more precisely metapyridinophanes. There are various routes to these compounds and related