Search results
Search for "nanosponge" in Full Text gives 8 result(s) in Beilstein Journal of Organic Chemistry.
Mechanochemical green synthesis of hyper-crosslinked cyclodextrin polymers
Beilstein J. Org. Chem. 2020, 16, 1554–1563, doi:10.3762/bjoc.16.127
- were similar, however, with an interesting difference in the initial loss of water, which was due to the different water affinity of the CDs, resulting in different hygroscopy of the final materials. In Figure 4, a test on the ability of the β-CD-based carbonate nanosponge obtained through ball-mill
- synthesis to remove organic compounds from aqueous solutions is shown. As can be seen methyl red was completely removed from its solution by adding a small amount of the bm carbonate nanosponge (50 mg for 10 mL of an aqueous solution of methyl red, 50 ppm). As determined by DLS, the particle sizes of the
- quantity of CDI involved in this nanosponge as it was 2–4 times higher as for the other βNS-CDI, assuming that the kinetics and reactivity were the same in all experiments. As a consequence, the IMH and unreacted IM contents were higher. Noteworthy was that most of the CDI reacted in the crosslinking step
Polyaminoazide mixtures for the synthesis of pH-responsive calixarene nanosponges
Beilstein J. Org. Chem. 2019, 15, 633–641, doi:10.3762/bjoc.15.59
- providing no separation of the components. The mixtures were adequately characterized by means of combined HR-ESIMS, FTIR and NMR techniques and, despite their complexity, they were successfully used to accomplish the subsequent preparation of pH-sensitive calixarene hyper-reticulated nanosponge materials
- nanosponge materials with tunable properties. Nanosponges (NSs) [7][8][9][10][11][12][13][14] are hyper-cross-linked polymers or copolymers obtained by reacting supramolecular host species as the monomer units with suitable reticulating agents. Of course, the structural, physical and chemical features of the
- the 2:1:1 ratio expected on the grounds of numerical simulations. The separation of such a mixture would be unsuitable in view of a possible large-scale synthesis and application of the relevant nanosponge polymeric materials, because it should involve undesirable waste of time and materials. However
Hyper-reticulated calixarene polymers: a new example of entirely synthetic nanosponge materials
Beilstein J. Org. Chem. 2018, 14, 1498–1507, doi:10.3762/bjoc.14.127
- report on the synthesis and characterization (FTIR, solid-state NMR, SEM) of a new class of entirely synthetic nanosponge materials based on calixarenes (CaNSs), by reacting a tetrakis(propargyloxy)calix[4]arene with alkyl diazides. The synthesis was accomplished by means of a classical “click” approach
Dynamics and interactions of ibuprofen in cyclodextrin nanosponges by solid-state NMR spectroscopy
Beilstein J. Org. Chem. 2017, 13, 182–194, doi:10.3762/bjoc.13.21
- indicated that the structure of the nanosponge did not undergo changes upon drug loading compared to the unloaded system. However, the 13C NMR spectra collected under variable contact time cross-polarization (VCT-CP) conditions showed that the polymeric scaffold CDNS changed significantly its dynamic regime
- solid state products were prepared via freeze-drying of the hydrogels obtained by swelling the nanosponge with aqueous solutions of IbuNa. The main purpose of the present work is to investigate the structural changes of the host CDNS material as well as the drug chemical and structural modifications in
- involved in hydrogen bonds. The presence of such a signal provides evidence for two remarkable facts: i) the drug entrapped in the nanosponge is in the acidic form, and ii) the ibuprofen molecules hosted in the CDNS are fully involved in a hydrogen-bond network. This point is worth of a comment: racemic
Anomalous diffusion of Ibuprofen in cyclodextrin nanosponge hydrogels: an HRMAS NMR study
Beilstein J. Org. Chem. 2014, 10, 2715–2723, doi:10.3762/bjoc.10.286
- phosgene synthetic equivalent as carbonyldiimidazole (CDI) or diphenyl carbonate (DPC) [1][2][3]. For clarity, the corresponding nanosponge will be indicated as CDNS followed by the acronym of the cross-linker agent (e.g., CDNSEDTA for cyclodextrin nanosponge polymerized with the EDTA derivative). The
- , such as the chemical compositions of the nanosponge (e.g., CDNSPMA, CDNSEDTA are swellable, CDNSDPC are not) and the cross-linker to CD mole ratio n [17]. Recently, we demonstrated that the CDNS hydrogels undergo phase transitions by changing the hydration level h = m(H2O)/mCDNS by a complex interplay
- potential use in therapy. In this work we present a study based on HRMAS NMR spectroscopy on the transport properties of Ibuprofen sodium salt (IP) confined in CDNSEDTA nanosponge hydrogels. Here, two different formulation of the nanosponges are investigated, characterized by a different CD/cross linker
Synthesis and characterization of a hyper-branched water-soluble β-cyclodextrin polymer
Beilstein J. Org. Chem. 2014, 10, 2586–2593, doi:10.3762/bjoc.10.271
- amount of cross-linker is higher than this value the cross-linking agent is grafted to the CD polymer only from one side, thus leading to an increase of branching groups on the nanosponge structure. Now we have found that by working under limited dilution conditions and with a high cross-linker/CD ratio
- ring opening reaction of the cyclic dianhydride and the formation of ester bridges. Moreover, the relative intensity of the O–H stretching band (centered at 3435 cm−1) with respect to the intensity of the carbonyl stretching band is higher in the branched polymer than in the cross-linked nanosponge
- , that is because the branched polymer contains an higher number of OH groups that under different, less controlled reaction conditions would have reacted with pyromellitic dianhydride to give ester cross-links and an hyper-cross-linked nanosponge. The O–H stretching band can be ascribed to both primary
Cyclodextrin-based nanosponges as drug carriers
Beilstein J. Org. Chem. 2012, 8, 2091–2099, doi:10.3762/bjoc.8.235
- swelling properties. The polarity and dimension of the polymer mesh can be easily tuned by varying the type of cross-linker and degree of cross-linking. Nanosponge functionalisation for site-specific targeting can be achieved by conjugating various ligands on their surface. They are a safe and
- observed after 2 h due to degradation of the nanosponge structure, whereas the basic environment did not affect the nanosponge stability. On the other hand, carboxylated nanosponges obtained by using pyromellitic dianhydride as a cross-linker appear less chemically and thermally stable, but can swell more
- structure that is formed changes many properties of the native cyclodextrin. This peculiar and versatile structure is suitable for a broad range of potential and actual applications and was recently reviewed [13][21][22][23]. As a general characteristic, the nanosponge structure improves the ability of
Cyclodextrin nanosponge-sensitized enantiodifferentiating photoisomerization of cyclooctene and 1,3-cyclooctadiene
Beilstein J. Org. Chem. 2012, 8, 1305–1311, doi:10.3762/bjoc.8.149
- )-cyclooctene and (Z,Z)-1,3-cyclooctadiene were performed by using the pyromellitate-linked cyclodextrin network polymer, termed “cyclodextrin nanosponge (CDNS)”, as a supramolecular sensitizing host. The photochirogenic behavior of the nanosponges incorporating β- or γ-cyclodextrin was significantly different
- the photochirogenic reaction. Keywords: cyclodextrins; 1,3-cyclooctadiene; cyclooctene; nanosponge; photochirogenesis; photoisomerization; Introduction The precise control of chiral photoreactions, or photochirogenesis, is one of the most challenging topics in current photochemistry [1][2][3]. Weak
- convenient and also powerful tool for manipulating the stereochemical outcomes of supramolecular photochirogenesis. It should be noted that γ-CD-based nanosponge 5 gave the highest ee values for both 1E and 2EZ. This is in sharp contrast to the result reported for the photosensitization with conventional
Other Beilstein-Institut Open Science Activities
