Ligand effects, solvent cooperation, and large kinetic solvent deuterium isotope effects in gold(I)-catalyzed intramolecular alkene hydroamination

• Ruichen Lan,
• Brock Yager,
• Yoonsun Jee,
• Cynthia S. Day and
• Amanda C. Jones

Beilstein J. Org. Chem. 2024, 20, 479–496, doi:10.3762/bjoc.20.43

• catalyzed by triflic acid and the gold π-activation pathway was questioned [26]. Nevertheless, advancements in gold-catalyzed reactions continued to be achieved. In particular, successful asymmetric methods were reported in short time after initially reported non-asymmetric methods, specifically Kojima’s

Synergistic chiral iminium and palladium catalysis: Highly regio- and enantioselective [3 + 2] annulation reaction of 2-vinylcyclopropanes with enals

• Haipan Zhu,
• Peile Du,
• Jianjun Li,
• Ziyang Liao,
• Guohua Liu,
• Hao Li and
• Wei Wang

Beilstein J. Org. Chem. 2016, 12, 1340–1347, doi:10.3762/bjoc.12.127

• important challenges. To the best of our knowledge, so far merely two catalyst manifolds have been realized to effect the transformations with C=C double bonds instead of C=O in the α,β-unsaturated systems. Tsuji described the first organometallic promoted non-asymmetric reaction between D–A cyclopropanes

Enantioselective additions of copper acetylides to cyclic iminium and oxocarbenium ions

• Jixin Liu,
• Srimoyee Dasgupta and
• Mary P. Watson

Beilstein J. Org. Chem. 2015, 11, 2696–2706, doi:10.3762/bjoc.11.290

• –77%), but poor enantioselectivities (1–11% ee). However, the use of activated acetylenes provides a functional group handle for elaboration, which the authors demonstrate in the preparation of indolizidine 223AB. Building on their initial discovery of a non-asymmetric, copper-catalyzed, three

Mechanochemistry assisted asymmetric organocatalysis: A sustainable approach

• Pankaj Chauhan and
• Swapandeep Singh Chimni

Beilstein J. Org. Chem. 2012, 8, 2132–2141, doi:10.3762/bjoc.8.240

• synthetic organic chemistry has increased considerably, due to the need for development of sustainable methodologies, and has been widely used in solvent-free non-asymmetric transformations. On the other hand, demands for the development of stereoselective synthesis of organic molecules have noticeably

Organocatalytic C–H activation reactions

• Subhas Chandra Pan

Beilstein J. Org. Chem. 2012, 8, 1374–1384, doi:10.3762/bjoc.8.159

• non-asymmetric and asymmetric C–H activation reactions mediated by organocatalysts are discussed in this review. Keywords: asymmetric; C–H activation; non-asymmetric; organocatalysis; organocatalytic; Introduction C–H activation reactions have recently been found to be a powerful method for the

• transformations will not be covered in this review. Review Organocatalytic sp3 C–H bond activation reactions Non-asymmetric variants tert-Amino effect: The “tert-amino effect” refers to the ring-closure reactions that proceed by redox processes for C–C and C–X bond formation within conjugated systems [7][8][9

• non-asymmetric version of the reaction using pyrrolidine-TFA as catalyst in acetonitrile. High yields (67–98%) and moderate to good diastereoselectivities (59:41 to 80:20) were obtained for amine donors of different ring size [24]. After successfully performing the non-asymmetric synthesis of