Beilstein J. Org. Chem.2014,10, 2677–2682, doi:10.3762/bjoc.10.282
Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China 10.3762/bjoc.10.282 Abstract An unusual C18 norditerpenoid, aspergiloid I (1), was isolated from the culture broth of Aspergillus sp. YXf3, an endophytic fungus
carbon skeleton with an unprecedented 6/5/6 tricyclic ring system bearing an α,β-unsaturated spirolactone moiety in ring B, and represents a new subclass of norditerpenoid, the skeleton of which is named aspergilane. The hypothetical biosynthetic pathway for 1 was also proposed. The cytotoxic
, antimicrobial, anti-oxidant and enzyme inhibitory activities of 1 were evaluated.
Keywords: Aspergillus; endophytic fungus; Ginkgo biloba; natural product; norditerpenoid; Trichocomaceae; Introduction
Plant-derived fungi, which have drawn considerable attention from natural product chemists, have been proved
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Graphical Abstract
Figure 1:
Structure of aspergiloid I (1) and its novel skeleton.