On drug discovery against infectious diseases and academic medicinal chemistry contributions

• Yves L. Janin

Beilstein J. Org. Chem. 2022, 18, 1355–1378, doi:10.3762/bjoc.18.141

• chemical libraries. With a very different starting point but also on the malaria front, the remarkable ozonides OZ277/arterolane (41) [210][211] and OZ439/artefenomel (42) [212][213][214] stemmed from academic collaborations across the world which started in 2000. While arterolane (41) is a drug used in

• therapy [221][224]. It then took quite a while to balance in this class of antimalarial a requirement for a reactive component with an acceptable human pharmacological profile. This was reached with the ozonides 41 and 42 which, in lights of the perpetual selection of drug-resistant Plasmodium strains

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

• Guido Gambacorta,
• James S. Sharley and
• Ian R. Baxendale

Beilstein J. Org. Chem. 2021, 17, 1181–1312, doi:10.3762/bjoc.17.90

Rearrangements of organic peroxides and related processes

• Ivan A. Yaremenko,
• Vera A. Vil’,
• Dmitry V. Demchuk and
• Alexander O. Terent’ev

Beilstein J. Org. Chem. 2016, 12, 1647–1748, doi:10.3762/bjoc.12.162

Cp₂TiCl/D₂O/Mn, a formidable reagent for the deuteration of organic compounds

• Antonio Rosales and
• Ignacio Rodríguez-García

Beilstein J. Org. Chem. 2016, 12, 1585–1589, doi:10.3762/bjoc.12.154

• (Scheme 1). This SET is capable of promoting and/or catalyzing several transformations in organic chemistry [17][18][19][20][21][22][23][24][25]. One of the most relevant transformations is the H/D-atom transfer from H2O/D2O to carbon radicals (pathway A) (obtained from epoxides [26][27][28], ozonides [29

• epoxides [2][27][37], ozonides [29], ketones [31][32], activated halides [30][31][32], alkenes and alkynes [33]. Several examples are presented in Scheme 3. The results show that the combination Cp2TiCl/D2O/Mn is able to promote and/or catalyze deuteration of organic compounds by reduction or radical

• summary, we presented an overview of the Cp2TiCl/D2O/Mn combination as an efficient, cheap, selective, and sustainable reagent compatible with different functional groups that mediates the deuteration of organic compounds from epoxides, ozonides, carbonyl compounds, activated halides, alkenes and alkynes

Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products

• Alexander O. Terent'ev,
• Dmitry A. Borisov,
• Vera A. Vil’ and
• Valery M. Dembitsky

Beilstein J. Org. Chem. 2014, 10, 34–114, doi:10.3762/bjoc.10.6

• .10.6 Abstract The present review describes the current status of synthetic five and six-membered cyclic peroxides such as 1,2-dioxolanes, 1,2,4-trioxolanes (ozonides), 1,2-dioxanes, 1,2-dioxenes, 1,2,4-trioxanes, and 1,2,4,5-tetraoxanes. The literature from 2000 onwards is surveyed to provide an update

• , and antitumor agents. Keywords: cyclic peroxides; 1,2-dioxanes; 1,2-dioxenes; 1,2-dioxolanes; ozonides; 1,2,4,5-tetraoxanes; 1,2,4-trioxanes; 1,2,4-trioxolanes; Introduction Approaches to the synthesis of five and six-membered cyclic peroxides, such as 1,2-dioxolanes I, 1,2,4-trioxolanes (ozonides

• -trioxolanes can be trapped with allyltrimethylsilane. For example, the SnCl4-mediated fragmentation of ozonides 84a–l in the presence of allyltrimethylsilane in dichloromethane gives a complex mixture of products 85–94, including dioxolanes 86a–i, 87i, 90j–l, and 91j (Scheme 25, Table 8) [256]. Treatment of