Beilstein J. Org. Chem.2017,13, 2252–2263, doi:10.3762/bjoc.13.222
/bjoc.13.222 Abstract The complexation of the antifolate pemetrexed (PTX) with native cyclodextrins was studied. This process, along with the findings gathered for the structurally related folic acid was treated as a model for exploiting host–guest interactions of this class of guest molecules in the
; pemetrexed; supramolecular chemistry; Introduction
Herein, supramolecular host–guest complexes of the potent folic acid inhibitor pemetrexed (PTX, Figure 1a) with native cyclodextrins (α-, β- and γ-CDs, Figure 1b) in the gas phase (MS), in solution (NMR, UV–vis) and in the solid state (Raman, FTIR–ATR) were
complexes is a highly attractive way to overcome these unwanted features [8]. One of such chemotherapeutic drugs is pemetrexed (PTX), developed initially in 2004 for the treatment of non-small lung cancer [9]. This type of cancer is the most commonly appearing cancer in the world [10] and its treatment
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Graphical Abstract
Figure 1:
Molecular structures with atom numbering of the guest (a: from left to right): pemetrexed (PTX) and...