New hydrogen-bonding organocatalysts: Chiral cyclophosphazanes and phosphorus amides as catalysts for asymmetric Michael additions

• Helge Klare,
• Jörg M. Neudörfl and
• Bernd Goldfuss

Beilstein J. Org. Chem. 2014, 10, 224–236, doi:10.3762/bjoc.10.18

• the catalyst. Keywords: DFT computations; hydrogen bonding; Michael addition; organocatalysis; phosphazanes; Introduction Organocatalysis has gained great impact in promoting highly enantioselective [1][2][3][4] and eco-friendly [5] reactions. Within the field of organocatalysis hydrogen-bonding (HB

• attempted a cis-selective synthesis of bis(amido)cyclodiphosphazanes, which also allows a more modular approach to the design of catalysts. The generation of cyclic cis-di(PIII)phosphazanes from bulky aliphatic amines is well known [38]. In most cases the dichloro derivatives can be obtained in a cis