Beilstein J. Org. Chem.2014,10, 996–1005, doi:10.3762/bjoc.10.99
. Interestingly, in the presence of wet trifluoroacetic acid, in addition to phosphinoylisocoumarins, phosphorus-free isocoumarins were also obtained. Key products were characterized by single crystal X-ray crystallography.
Keywords: allenes; indoles; isocoumarins; organophosphorus; phosphinoyl-heterocycles
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Graphical Abstract
Scheme 1:
Reaction of P(III)-Cl precursors with propargyl alcohols leading to phosphorus based (a) N-hydroxyi...