Beilstein J. Org. Chem.2019,15, 2003–2012, doi:10.3762/bjoc.15.196
physalins, perulactones and 4ß-hydroxywithanolide E (1) [5][6][7][8][9][10][11][12][13][14][15][16]. As part of our ongoing programme focussed on the biochemistry of withanolides, our aim was to gain further insights into the withanolide profile of P. peruviana. Here we report irinans A (2) and B (3), two
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Graphical Abstract
Figure 1:
Withanolides from Physalis peruviana. A) Structures of the newly characterised truncated withanolid...
Beilstein J. Org. Chem.2014,10, 134–140, doi:10.3762/bjoc.10.10
Chemistry, University of Dhaka, Dhaka-1000, Bangladesh 10.3762/bjoc.10.10 Abstract Hedgehog (Hh) signaling plays an important role in embryonic development, cell maintenance and cell proliferation. Moreover, Hh signaling contributes to the growth of cancer cells. Physalins are highly oxidized natural
products with a complex structure. Physalins (1–7) were isolated from Solanum nigrum (Solanaceae) collected in Bangladesh by using our cell-based assay. The isolated physalins included the previously reported Hh inhibitors 5 and 6. Compounds 1 and 4 showed strong inhibition of GLI1 transcriptional activity
, and exhibited cytotoxicity against cancer cell lines with an aberrant activation of Hh signaling. Compound 1 inhibited the production of the Hh-related proteins patched (PTCH) and BCL2. Analysis of the structures of different physalins showed that the left part of the physalins was important for Hh
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Graphical Abstract
Figure 1:
Schematic procedure of the constructed assay system; Tc (tetracycline), TetR (tetracycline represso...