Beilstein J. Org. Chem.2023,19, 1299–1369, doi:10.3762/bjoc.19.96
compounds.
Keywords: amphiphiles; edelfosine; GAEL; glycerol lipids; glycolipids; ohmline; plasmalogen; Introduction
Ether lipids (ELs) are natural compounds that feature a glycerol unit linked with an ether function to an alkyl (alkyl acyl ether lipid) or alkenyl (plasmalogen) lipid chain. For the
distribution is heterogeneous with abundant amount (up to 50% of the phosphoethanolamine based lipids) in central nervous system (mainly as PE-plasmalogen), in skeletal muscle, heart, kidney and lungs [13]. At a cellular scale, the biosynthesis of ELs is initiated in peroxisome and maturation is completed in
Parkinson disease [18], breast cancer [19] and in rectal adenocarcinoma [20] (in the last case by measuring lysophosphatidylcholine plasmalogen). Low levels of ether lipids are reported in inherited peroxisomal disorders (e.g., rhizomelic chondrodysplasia punctata or Zellweger syndrome) [21]. The severity
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Graphical Abstract
Figure 1:
Chemical structure of some natural ether lipids (ELs).