Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide

• Lena Möller,
• Christian Hess,
• Jiří Paleček,
• Yi Su,
• Axel Haverich,
• Andreas Kirschning and
• Gerald Dräger

Beilstein J. Org. Chem. 2013, 9, 270–277, doi:10.3762/bjoc.9.33

• , leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells. Keywords: click chemistry; growth factor; nitrenes; plasma chemistry; poly(4-methylpent-1-ene

• peptide amounts to 46 Å. Access by integrins again decreases when the spacer is longer and likely folds in such a way that RGDs become less surface-exposed [34]. Conclusion In conclusion we developed a protocol for functionalizing polyhydrocarbons, here poly(4-methylpent-1-ene) (TPX), which are important

• ) functionalized TPX 7b with PEG and oxanorbonadiene group; (g) functionalized TPX 8b with cRGD (copper-free approach). Functionalization of poly(4-methylpent-1-ene) (TPX) 2. Copper-catalyzed and copper-free azide–alkyne “click“ reaction between functionalized TPX membranes 7a or 7b and cRGD peptide 1b or with