Poly(glycolide) multi-arm star polymers: Improved solubility via limited arm length

• Florian K. Wolf,
• Anna M. Fischer and
• Holger Frey

Beilstein J. Org. Chem. 2010, 6, No. 67, doi:10.3762/bjoc.6.67

• compared to the homopolymer PGA should lead to simplified processing conditions. The findings contribute to broadening the range of biomedical applications of PGA. Keywords: block copolymer; hyperbranched; PGA; polyester; polyglycerol; poly(glycolide); star polymer; Introduction Linear aliphatic

• crystallization tendencies of the polymer. Results and Discussion The hyperbranched poly(glycerol)s (PGs) with multiple poly(glycolide) arms were prepared by a straightforward two-step approach as shown in Figure 1. In the first step, we polymerized glycidol anionically by the method described previously [19

• a precise signal-to-structure correlation is difficult to establish, differentiation between PG and poly(glycolide) signals was achieved, confirming successful grafting of poly(glycolide) onto the PG core. Even more important, it was confirmed that the majority of the hydroxy groups of PG