Asymmetric 1,4-bis(ethynyl)bicyclo[2.2.2]octane rotators via monocarbinol functionalization. Ready access to polyrotors

• Cyprien Lemouchi and
• Patrick Batail

Beilstein J. Org. Chem. 2015, 11, 1881–1885, doi:10.3762/bjoc.11.202

• and polyrotors demonstrates the efficiency of this strategy. Keywords: bridging ligands; molecular rotors; polyrotors; Findings Synthesis-informed design [1] of rotors is essential to the development of molecular machines [2][3][4][5]. Recent advances in the chemistry of functional rotors with a 1,4

• diversity of polyrotors. The salient feature of this synthesis lies in its generic character because 4-(4-ethynylbicyclo[2.2.2]octan-1-yl)-2-methylbut-3-yn-2-ol, (1) (Scheme 1), the single precursors of many diverse targets, is readily obtained. The choice of the carbinol protecting group was dictated on