Beilstein J. Org. Chem.2011,7, 735–739, doi:10.3762/bjoc.7.83
Hidekazu Oyamada Takeshi Naito Shu Kobayashi Department of Chemistry, School of Science and Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan 10.3762/bjoc.7.83 Abstract Continuous flow systems for hydrogenation using polysilane-supported
. The catalyst retained high activity for at least 8 h under neat conditions.
Keywords: flow chemistry; hydrogenation; polysilane; palladium; reduction; Findings
Catalytic hydrogenation is one of the most important methods for the reduction of C–C double and triple bonds, and other functional groups
and substantially increase production.
We also recently reported novel transition metal catalysis involving the immobilization of Pd or Pt onto polysilane supports by the microencapsulation method [12]. The Pd catalyst (Pd/PSi) had high activity with no or very little leaching of Pd, and it could be
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Graphical Abstract
Figure 1:
Schematic diagram of the continuous flow reactor (left) and the column top (right).