Beilstein J. Org. Chem.2013,9, 510–515, doi:10.3762/bjoc.9.55
-diaminobenzene, dialkyl acetylenedicarboxylates, and ethyl bromopyruvate forms pyrrolo[1,2-a]quinoxaline derivatives in good yields. Ethylenediamine also reacts under similar conditions to produce new pyrrolo[1,2-a]pyrazine derivatives.
Keywords: acetylenedicarboxylates; benzene-1,2-diamine; ethyl bromopyruvate
; pyrrolo[1,2-a]pyrazine; pyrrolo[1,2-a]quinoxaline; Introduction
Among the various classes of heterocyclic compounds, quinoxalines, a class of N-containing heterocycles, form an important component of many pharmacologically active compounds [1][2][3][4]. For example, the quinoxaline ring is a constituent
research area. The syntheses of pyrrolo[1,2- a]isoquinolines have previously been reported by us [28]. In this paper, we describe a simple synthesis of functionalized pyrrolo[1,2-a]quinoxaline and pyrrolo[1,2-a]pyrazine derivatives in the absence of catalysts.
Results and Discussion
The reaction of 1,2
PDF
Graphical Abstract
Scheme 1:
Proposed mechanism for the formation of compound 4a.