Indolizines and pyrrolo[1,2-c]pyrimidines decorated with a pyrimidine and a pyridine unit respectively

• Marcel Mirel Popa,
• Emilian Georgescu,
• Mino R. Caira,
• Florentina Georgescu,
• Constantin Draghici,
• Raluca Stan,
• Calin Deleanu and
• Florea Dumitrascu

Beilstein J. Org. Chem. 2015, 11, 1079–1088, doi:10.3762/bjoc.11.121

• structures of two of the starting materials, 4-(2-pyridyl)pyrimidine and 4-(4-pyridyl)pyrimidine, are also reported. Keywords: indolizine; nitrogen heterocycles; N-ylide; 4-pyridylpyrimidine; pyrrolo[1,2-c]pyrimidine; Introduction Two heteroarenes linked through a single bond [1] proved to be versatile

• corresponding pyrrolo[1,2-a]pyrimidine was observed as previously reported by us [31][32]. The yields were moderate to good. The NMR data of compounds 12 show strong evidence for the formation of the new compounds. The main 1H NMR features are the signals in the pyrrolo[1,2-c]pyrimidine which were assigned by

• -(2-Pyridyl)-5-acetyl-7-(4-bromobenzoyl)-pyrrolo[1,2-c]pyrimidine (12a). Pale yellow powder with mp 263–265 °C. Yield 41%. Anal. calcd for C21H14BrN3O2: C, 60.02; H, 3.36; Br, 19.01; N, 10.00; found: C, 60.30; H, 3.65; Br, 19.24; N, 10.22; 1H NMR (CDCl3, 300 MHz) δ 2.60 (CH3), 7.64 (s, 4H, H-2”, H-3