The digital code driven autonomous synthesis of ibuprofen automated in a 3D-printer-based robot

• Philip J. Kitson,
• Stefan Glatzel and
• Leroy Cronin

Beilstein J. Org. Chem. 2016, 12, 2776–2783, doi:10.3762/bjoc.12.276

• was used to 3D print reaction vessels (reactionware) of differing internal volumes using polypropylene feedstock via a fused deposition modeling 3D printing approach and subsequently make use of these fabricated vessels to synthesize the nonsteroidal anti-inflammatory drug ibuprofen via a consecutive

• being applied to scientific disciplines as diverse as biomedical research [7][8][9], soft robotics [10][11] and materials science [12]. Our group has recently been investigating the use of 3D printing in the chemical sciences, in particular its potential to create ‘reactionware’ [13], that is, chemical

Camera-enabled techniques for organic synthesis

• Steven V. Ley,
• Richard J. Ingham,
• Matthew O’Brien and
• Duncan L. Browne

Beilstein J. Org. Chem. 2013, 9, 1051–1072, doi:10.3762/bjoc.9.118

• mixing was constant for the required time. Supporting Information File 2 shows the device in operation. Cronin and co-workers have recently reported the use of three-dimensional design software and an open-hardware 3D printing device to produce low-cost bespoke reactionware for applications in both

3D-printed devices for continuous-flow organic chemistry

• Vincenza Dragone,
• Victor Sans,
• Mali H. Rosnes,
• Philip J. Kitson and
• Leroy Cronin

Beilstein J. Org. Chem. 2013, 9, 951–959, doi:10.3762/bjoc.9.109

• processing advantages of flow chemistry for the synthesis of organic compounds. Robust and inexpensive 3D-printed reactionware devices are easily connected using standard fittings resulting in complex, custom-made flow systems, including multiple reactors in a series with in-line, real-time analysis using an

• synthesis; millifluidics; reactionware; Introduction The use of flow chemistry and 3D-printing technology is expanding in the field of organic synthesis [1][2][3][4][5]. The application of continuous-flow systems is frequently found in chemistry, and is beginning to have a significant impact on the way

• molecules are made [1][2][3]; on the other hand the application of 3D-printing technology in synthetic chemistry still has many aspects that can be investigated. The benefits resulting from the utilization of 3D-printing techniques to create bespoke reactionware for synthetic chemistry have recently been