Continuous-flow Heck synthesis of 4-methoxybiphenyl and methyl 4-methoxycinnamate in supercritical carbon dioxide expanded solvent solutions

• Phei Li Lau,
• Ray W. K. Allen and
• Peter Styring

Beilstein J. Org. Chem. 2013, 9, 2886–2897, doi:10.3762/bjoc.9.325

• . It is clear that within experimental error that the TOFs in the two reactor configurations are essentially identical which is encouraging in terms of the ability to both scale up and scale out the reactions. The TOF is defined as the number of moles of substrate converted per mol of catalyst per unit

Ethyl diazoacetate synthesis in flow

• Mariëlle M. E. Delville,
• Jan C. M. van Hest and
• Floris P. J. T. Rutjes

Beilstein J. Org. Chem. 2013, 9, 1813–1818, doi:10.3762/bjoc.9.211

• conditions, a production yield of 20 g EDA day−1 was achieved using a microreactor with an internal volume of 100 μL. Straightforward scale-up or scale-out of microreactor technology renders this method viable for industrial application. Keywords: diazo compounds; diazotization; ethyl diazoacetate (EDA

• immediately used for either batch [13][15] or continuous-flow [16][17] follow-up reactions. Straightforward scale-up or scale-out of microreactor technology renders this method viable for industrial application. Results and Discussion Flow synthesis Ethyl diazoacetate (1) was synthesized from glycine ethyl

From discovery to production: Scale- out of continuous flow meso reactors

• Peter Styring and
• Ana I. R. Parracho

Beilstein J. Org. Chem. 2009, 5, No. 29, doi:10.3762/bjoc.5.29

• a full analysis. By replication of the single reactor in parallel, the same chemistry can be achieved on a larger scale, on a small footprint and without the mass and heat transport limitations of reactor scale-out in batch. Keywords: catalysis; continuous flow; Kumada reaction; parallel; scale-out

• temperature, using a nickel catalyst supported on Merrifield resin beads in a Swagelok meso reactor column, which is of the same dimensions as a single channel in a scaled-out parallel capillary reactor. The objective of this research was to demonstrate that it is possible practically to scale-out a reaction