Beilstein J. Org. Chem.2024,20, 101–117, doi:10.3762/bjoc.20.11
irradiation of the styrylpyridines and formation of the intercalator directly in the presence of DNA. In addition to the DNA-binding properties, the tested benzo[c]quinolizinium derivatives also operate as photosensitizers, which induce DNA damage at relative low concentrations and short irradiation times
; heterocycles; photocyclization; photosensitizer; styrylpyridines; Introduction
DNA intercalators – most often represented by small planar heteroaromatic compounds – play an important role as chemotherapeutic agents [1][2][3][4]. Specifically, upon intercalation into the DNA double helix such ligands can cause
spectrometry. In all cases, the E-configuration of the alkene double bonds was indicated by characteristic coupling constants of the alkene protons (3JH–H = 16 Hz).
Absorption properties and photoreactions of styrylpyridine derivatives
In acetonitrile solution, the styrylpyridines 2a–g exhibited long
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Graphical Abstract
Scheme 1:
Photoinduced formation of benzo[c]quinolizinium and its interaction with DNA upon intercalation.
Beilstein J. Org. Chem.2019,15, 2170–2183, doi:10.3762/bjoc.15.214
oxidized to phenantrene in the presence of oxygen [48]. In high concentrations, (E)-stilbene furthermore undergoes photocyclodimerization to cyclobutane derivatives [49]. Photoisomerization and photocyclization are also reported for 3-styrylpyridines, forming two regioisomeric dihydroazaphenanthrenes that
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Graphical Abstract
Figure 1:
Selisistat (1) and hit compound GW435821X (2a).