Beilstein J. Org. Chem.2021,17, 1712–1724, doi:10.3762/bjoc.17.119
was found to regulate sulfotransferase NDST1 (ρ = 0.41, RP = 0.67).
Linking cell signaling to TF and glycogenes for basal breast cancer
Fewer TFs were found to be enriched to signaling pathways in basal breast cancer compared to luminal cancer (Figure 4b). Despite this, there are many other TF
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Graphical Abstract
Figure 1:
A systems glycobiology framework to link multi-OMICs data. a) Cell signaling proceeds to trigger TF...
Beilstein J. Org. Chem.2017,13, 2408–2415, doi:10.3762/bjoc.13.238
mediomycins are actually biosynthesised not by use of a different starter unit but by direct late-stage deamidination of (desulfo)clethramycin. A gene (slf) encoding a candidate sulfotransferase has been located in both gene clusters. Deletion of this gene in DSM4137 led to accumulation of desulfoclethramycin
, a rare case where an essential biosynthetic gene is not co-located with other pathway genes. Clearly, both desulfoclethramycin and clethramycin are substrates for this amidinohydrolase. Also, purified recombinant sulfotransferase from DSM4137, in the presence of 3'-phosphoadenosine-5'-phosphosulfate
as donor, efficiently converted mediomycin B to mediomycin A in vitro. Thus, in the final steps of mediomycin A biosynthesis deamidination and sulfotransfer can take place in either order.
Keywords: amidinohydrolase; clethramycin; mediomycin; polyketide synthase; sulfotransferase; Introduction
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Graphical Abstract
Scheme 1:
The structures of clethramycin, mediomycins and related linear polyenes.