Biantennary oligoglycines and glyco-oligoglycines self-associating in aqueous medium

• Svetlana V. Tsygankova,
• Alexander A. Chinarev,
• Alexander B. Tuzikov,
• Nikolai Severin,
• Alexey A. Kalachev,
• Juergen P. Rabe,
• Alexandra S. Gambaryan and
• Nicolai V. Bovin

Beilstein J. Org. Chem. 2014, 10, 1372–1382, doi:10.3762/bjoc.10.140

• assembling glycopeptides demonstrated an antiviral potency which was up to 50 times higher than the activity of peptide-free glycans. Keywords: glycopeptides; influenza virus; multivalent glycosystems; oligoglycine; polyglycine II; self-assembling; tectomers; Introduction Recently, we have synthesized and

• called tectomers. Tectomers in a layer are packed by polyglycine II type (PG II) [4][5]. Their helical polypeptide chain fundamentally differs from the canonical α-helix. The association of symmetrical tetra- and triantennary (star-like) oligoglycines spontaneously proceeds only when the number of

• were determined by using SFM and compared with: 1) those for tectomers (attributed to PG II, see above) formed in solution and 2) calculated values for different, not only PG II, models. As shown below for particular examples, in most cases spontaneous and surface-mediated assembly led to associates of