Beilstein J. Org. Chem.2010,6, 922–931, doi:10.3762/bjoc.6.98
nanoparticles; immobilization matrix; thermoflocculation; Introduction
The use of an external stimulus for the activation of (bio)chemical reaction processes can be a valuable tool in fundamental research and in applications such as reaction kits or lab-on-a-chip systems, as it allows for on-demand triggering
response. Thus the agglomerated particles can be separated easily by low magnetic field gradients, and facilitate, for instance, the separation process in purification applications of biomolecules.
Reversible thermoflocculation of magnetic colloids by encapsulation with thermoresponsive polymers has been
polymer brush on the surface of single nanoparticles has proved to be a valuable tool for the design of single-cored hybrid structures with tailored dispersion behavior [17][18][19][21][27][28][29][30]. Magnetic polymer brushes with thermoflocculation behavior have been reported for organic solvents by
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Graphical Abstract
Scheme 1:
Synthesis of magnetic biocatalyst particles.