Beilstein J. Org. Chem.2017,13, 257–266, doi:10.3762/bjoc.13.29
] and aromatic amidines resulted in glyoxalate-substituted pyrido[1,2-a]pyrimidinone, thiazolo[3,2-a]pyrimidinone and pyrimido[1,2-a]benzimidazole. Pyrazinones and quinoxalinones were obtained through the reaction of these glyoxalates with ethylenediamine and 1,2-phenylenediamine derivatives. On the
; quinoxalinone; thiazolo[3,2-a]pyrimidinone; Introduction
Various syntheses of polyazaheterocycles are described in the literature because they are important components for the preparation of bioactive molecules [1][2][3]. One of the most important synthetic methods towards compounds containing nitrogen atoms
, and elemental analysis. The structures of compounds 6, 9c, and 12g were additionally confirmed via crystallographic data (Figure 1).
Conclusion
The synthesis of pyrido[1,2-a]pyrimidinone, thiazolo[3,2-a]pyrimidinone, and pyrimidobenzimidazole polyazaheterocycles through the cyclocondensation reactions
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Graphical Abstract
Scheme 1:
Mechanism proposed for the formation of compound 5.